Photo by Southernmost Illinois Tourism Bureau

Plan, book, travel with confidence

Better together

Save up to ₹43,962 when you book a flight and hotel together*

Find the right fit

With over 300,000 hotels worldwide, it's easy to create a perfect package

Rest easy

Plan, book, and manage your trip all in one place

Top Adventure Southwest Illinois Hotels

SureStay Hotel by Best Western Whittington Rend Lake

13277 Freeway Lane, Whittington, IL

1 hour drive from Southern Illinois University

Stay at this business-friendly hotel in Whittington. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the helpful staff and the clean rooms ...

8.8/10 Excellent! (876 reviews)

I stayed 1 night for a layover from driving. Room was comfortable, quiet and clean. Excellent accomodations. Easy check in. Breakfast was simple but adequate for what I needed. Cereal, fruit, toast, juice, coffee, etc. No hot options but every was excellent. Price point was very good and ratings ...

Reviewed on 18 Oct 2025

Hampton Inn Carbondale

2175 Reed Station Pkwy, Carbondale, IL

10 min drive from Southern Illinois University

Stay at this business-friendly hotel in Carbondale. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the helpful staff and the clean rooms ...

8.4/10 Very Good! (591 reviews)

Staff was very friendly and helpful

Reviewed on 17 Oct 2025

Days Inn & Suites by Wyndham Caseyville

2423 Old Country Inn Drive, Caseyville, IL

3 hours drive from Southern Illinois University

Stay at this business-friendly hotel in Caseyville. Enjoy free breakfast, free Wi-Fi and free parking. Popular attractions Pleasant Ridge Park and Cahokia Mounds ...

3.8/10 (322 reviews)

They are going to the best place to stay over there when they started to bring breakfast again. That's the best thing they had but they are leaving the best thing they had.

Reviewed on 15 Oct 2025

See all 719 properties in Southwest Illinois

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.