Photo by Southernmost Illinois Tourism Bureau

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Top Adventure Southwest Illinois Hotels

SureStay Hotel by Best Western Whittington Rend Lake

13277 Freeway Lane, Whittington, IL

1 hour drive from Southern Illinois University

Stay at this business-friendly hotel in Whittington. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the helpful staff and the clean rooms ...

8.8/10 Excellent! (830 reviews)

"Quiet place. Going through some renovations and our room was updated nicely."

Reviewed on 10 Jul 2025

Hampton Inn Carbondale

2175 Reed Station Pkwy, Carbondale, IL

10 min drive from Southern Illinois University

Stay at this business-friendly hotel in Carbondale. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the helpful staff and the clean rooms ...

8.4/10 Very Good! (569 reviews)

"Will be back"

Reviewed on 5 Jul 2025

Days Inn & Suites by Wyndham Caseyville

2423 Old Country Inn Drive, Caseyville, IL

3 hours drive from Southern Illinois University

Stay at this business-friendly hotel in Caseyville. Enjoy free breakfast, free Wi-Fi and free parking. Popular attractions Pleasant Ridge Park and Cahokia Mounds ...

3.8/10 (259 reviews)

"Maybe they need to repair the ice machine and bring back the snacks machines with card options. Maybe a convenient store inside. Repair the coin washer plus other things. But I still think it’s the best option to do the main things you do on a room: rest and be relaxed."

Reviewed on 30 Jun 2025

See all 684 properties in Southwest Illinois

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.