Search Hotels in Santa Ana, Antigua Guatemala

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Tonight
16 Dec - 17 Dec
Tomorrow
17 Dec - 18 Dec
This weekend
19 Dec - 21 Dec
Next weekend
26 Dec - 28 Dec

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Our top choices for Santa Ana hotels

Front of property
Casa Buho B&B

Casa Buho B&B

Casa Buho B&B
3.0 star property
Santa Ana
9.2 out of 10, Wonderful, (48)
"Great place !!"
United States
Abner Israel Polanco
The price is ₹4,704
₹5,738 total
includes taxes & fees
6 Jan - 7 Jan 2026
Casa Buho B&B
Front of property
Villas Santa Ana-Ricardo

Villas Santa Ana-Ricardo

Villas Santa Ana-Ricardo
3.5 star property
Santa Ana
8.6 out of 10, Excellent, (12)
"Space was clean and had a cozy vibe."
United States
Evelin
Villas Santa Ana-Ricardo
Garden view
Hostal Casa Buho

Hostal Casa Buho

Hostal Casa Buho
3.0 star property
Santa Ana
8.6 out of 10, Excellent, (21)
"Nice clean affordable accomodations and very accomodating and amicable hosts."
United States
Feng
The price is ₹4,305
₹5,252 total
includes taxes & fees
11 Jan - 12 Jan 2026
Hostal Casa Buho
Comfort Quadruple Room | Living area
Casa Quetzalli Los Nazarenos

Casa Quetzalli Los Nazarenos

Casa Quetzalli Los Nazarenos
2.0 star property
2.2 km from Santa Ana
9.4 out of 10, Exceptional, (24)
"The room was very clean and large. I stayed in room 1 and the car noises were very present but after a day of hiking it was not hard to fall asleep."
United States
Tina
The price is ₹2,344
₹2,859 total
includes taxes & fees
11 Jan - 12 Jan 2026
Casa Quetzalli Los Nazarenos
Property entrance
Hotel Soleil La Antigua

Hotel Soleil La Antigua

Hotel Soleil La Antigua
4.0 star property
1.8 km from Santa Ana
8.6 out of 10, Excellent, (1002)
"Great room"
United States
Elvin
Hotel Soleil La Antigua
Garden
Good Hotel Guatemala City

Good Hotel Guatemala City

Good Hotel Guatemala City
3.0 star property
23.9 km from Santa Ana
9.4 out of 10, Exceptional, (243)
"Great place to stay in the city"
United States
Cesar
The price is ₹8,693
₹10,605 total
includes taxes & fees
6 Jan - 7 Jan 2026
Good Hotel Guatemala City
Outdoor banquet area
Barceló Guatemala City

Barceló Guatemala City

Barceló Guatemala City
4.5 star property
22.7 km from Santa Ana
9.2 out of 10, Wonderful, (3118)
"Friendly staff , wonderful beds. Breakfast was great and large variety of foods. "
United States
Parker
The price is ₹6,070
₹7,406 total
includes taxes & fees
11 Jan - 12 Jan 2026
Barceló Guatemala City
Front of property
Why Not Hotel

Why Not Hotel

Why Not Hotel
3.0 star property
Historic Center, 1.5 km from Santa Ana
8.4 out of 10, Very good, (147)
"Great hotel! Absolutely recommend it. "
United States
Jorge
The price is ₹3,513
₹4,286 total
includes taxes & fees
17 Dec - 18 Dec
Why Not Hotel
Exterior
Naif Boutique Hotel

Naif Boutique Hotel

Naif Boutique Hotel
3.0 star property
Historic Center, 1.4 km from Santa Ana
9.0 out of 10, Wonderful, (372)
"Well located, friendly staff. Would stay again."
United States
Cristian Paolo
The price is ₹10,569
₹12,894 total
includes taxes & fees
21 Dec - 22 Dec
Naif Boutique Hotel
Reception
Hotel La Sin Ventura

Hotel La Sin Ventura

Hotel La Sin Ventura
2.0 star property
Historic Center, 1.3 km from Santa Ana
8.8 out of 10, Excellent, (143)
"Really glad we stayed here. This hotel has the best staff ever. Perfect location. "
United States
Greg
Hotel La Sin Ventura
Exterior
Hotel Panchoy

Hotel Panchoy

Hotel Panchoy
3.0 star property
Historic Center, 1.1 km from Santa Ana
8.4 out of 10, Very good, (274)
"Nice staff and good location "
United States
Luis
The price is ₹5,244
₹6,398 total
includes taxes & fees
5 Jan - 6 Jan 2026
Hotel Panchoy
Indoor pool, outdoor pool, pool loungers
Kawilal Hotel

Kawilal Hotel

Kawilal Hotel
3.5 star property
13.7 km from Santa Ana
9.0 out of 10, Wonderful, (132)
"Beautiful pool and spa with thermal water! Only hotel guests are allowed to have use of the installations. The massage was amazing! I would love to go back "
United States
Ana
The price is ₹9,765
₹11,914 total
includes taxes & fees
6 Jan - 7 Jan 2026
Kawilal Hotel
Property grounds
Casa Santa Rosa Hotel Boutique

Casa Santa Rosa Hotel Boutique

Casa Santa Rosa Hotel Boutique
3.5 star property
Historic Center, 1.5 km from Santa Ana
9.6 out of 10, Exceptional, (319)
"Excellent hotel. The property is incredible, with lush gardens and very quiet. Staff is friendly. Room were clean and comfortable. So would stay again."
United States
Alejandro
The price is ₹12,662
₹15,448 total
includes taxes & fees
18 Dec - 19 Dec
Casa Santa Rosa Hotel Boutique
Exterior
Hotel Posada de Don Rodrigo Antigua

Hotel Posada de Don Rodrigo Antigua

Hotel Posada de Don Rodrigo Antigua
3.5 star property
Historic Center, 1.5 km from Santa Ana
9.4 out of 10, Exceptional, (647)
"Friendly staff, clean rooms the location was excellent. "
United States
Elias
The price is ₹14,180
₹19,609 total
includes taxes & fees
27 Dec - 28 Dec
Hotel Posada de Don Rodrigo Antigua
Interior entrance
Tikal Futura Hotel & Convention Center

Tikal Futura Hotel & Convention Center

Tikal Futura Hotel & Convention Center
4.5 star property
20.2 km from Santa Ana
9.0 out of 10, Wonderful, (1007)
"Very nice hotel"
United States
Jeudy
The price is ₹9,727
₹11,866 total
includes taxes & fees
4 Jan - 5 Jan 2026
Tikal Futura Hotel & Convention Center
Garden
Hilton Guatemala City

Hilton Guatemala City

Hilton Guatemala City
4.5 star property
25.9 km from Santa Ana
8.6 out of 10, Excellent, (680)
"Great stay and amazing property "
United States
Hugo
The price is ₹9,359
₹11,417 total
includes taxes & fees
11 Jan - 12 Jan 2026
Hilton Guatemala City
Bar (on property)
Los Pasos Boutique Hotel & Spa

Los Pasos Boutique Hotel & Spa

Los Pasos Boutique Hotel & Spa
4.5 star property
0.7 km from Santa Ana
9.4 out of 10, Exceptional, (1003)
"Great place to stay. "
United States
tania
The price is ₹14,511
₹18,346 total
includes taxes & fees
8 Jan - 9 Jan 2026
Los Pasos Boutique Hotel & Spa
Interior
Ole España

Ole España

Ole España
2.5 star property
20.8 km from Santa Ana
9.4 out of 10, Exceptional, (27)
"Very nice hotel , just couldn’t walk anywhere, but great staff "
United States
John
The price is ₹5,371
₹6,553 total
includes taxes & fees
11 Jan - 12 Jan 2026
Ole España
Front of property
La Inmaculada Hotel

La Inmaculada Hotel

La Inmaculada Hotel
3.5 star property
23.7 km from Santa Ana
9.2 out of 10, Wonderful, (610)
"Everything was perfect, the room was perfectly cleaned every day, the restaurant is amazing, the people that wirks there amazing!!"
United States
Claudia
La Inmaculada Hotel
Exterior
Hotel Camino Real Antigua

Hotel Camino Real Antigua

Hotel Camino Real Antigua
4.0 star property
Historic Center, 1.4 km from Santa Ana
9.6 out of 10, Exceptional, (1006)
"Amazing hotel with beautiful gardens, great rooms, helpful staff and the top breakfast in Antigua. "
United States
Audrey
The price is ₹18,600
₹24,494 total
includes taxes & fees
17 Dec - 18 Dec
Hotel Camino Real Antigua
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Where to stay in Santa Ana

Find the best Santa Ana areas for the activities you enjoy most.

Historic Center

If you're spending some time in Historic Center, Central Park and Santa Catalina Arch are top sights worth seeing.

Barrio de La Concepción

While visiting Barrio de La Concepción, you might make a stop by sights like Casa Santo Domingo Museum and Jade Maya Factory and Museum.

Top Santa Ana Hotel Reviews

Hotel Soleil La Antigua

Hotel Soleil La Antigua

10/10 Excellent
"They gave me a room upgrade due to my VIP status and also offered the discount in food and beverages."
Victor 1-night trip
Posted 1 day ago
Hotel Soleil La Antigua

Explore a world of travel with Expedia

Frequently asked questions

What's it like in Santa Ana?
Travellers to the Santa Ana neighbourhood in Antigua Guatemala will be sure to enjoy their stay.
What's a favourite place to stay in Santa Ana?
Based on Expedia customer reviews, Casa Buho B&B is the highest ranked property in Santa Ana. This hotel offers a restaurant and free parking.
How many hotels will I be able to find in Santa Ana?
If you're searching for places to stay in Antigua Guatemala, choose from one of Expedia's 17 hotels and other accommodation options in Santa Ana.
If I need to cancel my hotel reservation in Santa Ana, will I receive a refund?
Yes! You'll find that most hotel reservations are fully refundable provided that you cancel prior to the hotel's cancellation deadline, which in most cases is within 24 or 48 hours of your scheduled arrival. If you booked a non-refundable reservation, it may still be possible to cancel it and be given a refund within 24 hours of your booking. Enter your dates, click on "Search", then use the "fully refundable" filter to view top deals in Santa Ana.
What are the top things to see and do in Santa Ana?
House of the Giants, Santa Clara Convent and Jade Maya Factory and Museum are just a few of the places to visit in and around Santa Ana. While you're out sightseeing in Antigua Guatemala, make sure that you visit other sights such as Tanque La Unión or Museo del Hermano Pedro.