A densely packed urban area with numerous buildings and a prominent tower on a hill.

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Check prices for these dates

This weekend
6 Nov - 8 Nov
Next weekend
13 Nov - 15 Nov

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Our top choices for Puerto Santa Ana hotels

A modern living room with a large window, a flat-screen TV, a sofa, and a coffee table.

1. Wyndham Guayaquil Puerto Santa Ana

Wyndham Guayaquil Puerto Santa Ana
4.5 star property
Puerto Santa Ana
9.4 out of 10, Exceptional, (1,003 reviews)
"Love staying at this hotel!"
United States
Isabel
The price is ₹10,426
₹11,706 total
29 Nov - 30 Nov
Wyndham Guayaquil Puerto Santa Ana
A laptop on a glass table with a plate of food and a chair in a room with a view of the sea.

2. River View suites Puerto Santa Ana gye

River View suites Puerto Santa Ana gye
3.0 star property
Puerto Santa Ana
9.0 out of 10, Wonderful, (67 reviews)
"Nice place to stay!"
United States
Aaliyah
The price is ₹7,431
₹8,475 total
10 Nov - 11 Nov
River View suites Puerto Santa Ana gye
A rooftop pool with a view of the city skyline.

3. Luxury Suites Riverfront GYE

Luxury Suites Riverfront GYE
3.5 star property
Puerto Santa Ana
9.4 out of 10, Exceptional, (112 reviews)
"So clean and very nice people. I really recommend this facility, nice environment. My next trip lm booking in this apartment"
United States
Pedro
The price is ₹7,541
₹7,636 total
18 Nov - 19 Nov
Luxury Suites Riverfront GYE
A grand room with ornate chandeliers, a large sofa, a round armchair, and a fireplace.

4. Mansión del Río

Mansión del Río
3.5 star property
Las Peñas, 0.6 km from Puerto Santa Ana
8.8 out of 10, Excellent, (151 reviews)
"The facility is very unique. Staff are very friendly. We have an early flight so did not get a chance to have breakfast."
United States
Shuyi
The price is ₹5,058
₹5,658 total
12 Nov - 13 Nov
Mansión del Río
A rooftop pool with a curved edge, lounge chairs, and potted plants.

5. Hotel Río Guayas by Art Hotels Ecuador

Hotel Río Guayas by Art Hotels Ecuador
4.0 star property
Las Peñas, 0.6 km from Puerto Santa Ana
10.0 out of 10, Exceptional, (5 reviews)
"Outstanding staff - great property"
United States
septimiu
The price is ₹28,626
₹31,950 total
4 Nov - 5 Nov
Hotel Río Guayas by Art Hotels Ecuador
An indoor swimming pool with clear blue water, surrounded by lounge chairs and potted plants.

6. Hotel Ramada

Hotel Ramada
3.0 star property
Downtown Guayaquil, 1.3 km from Puerto Santa Ana
8.0 out of 10, Very good, (422 reviews)
"Excelente atención, good service, sauna and pull in great condition, food very good"
United States
Pedro
The price is ₹5,979
₹6,074 total
9 Nov - 10 Nov
Hotel Ramada
A hot tub surrounded by palm trees and a brick wall, with a metal railing in the foreground.

7. Wyndham Garden Guayaquil

Wyndham Garden Guayaquil
3.5 star property
Simón Bolívar, 2.8 km from Puerto Santa Ana
9.2 out of 10, Wonderful, (1,003 reviews)
"Best hotel and great location food amazing"
United States
Giselle
The price is ₹7,596
₹8,498 total
7 Nov - 8 Nov
Wyndham Garden Guayaquil
A spacious living area with a sectional sofa, a round coffee table, and a large vase. There is a view of trees through the windows.

8. Unipark by Oro Verde Hotels

Unipark by Oro Verde Hotels
4.0 star property
Rocafuerte, 2 km from Puerto Santa Ana
9.4 out of 10, Exceptional, (1,002 reviews)
"Great for a short stay"
United States
Maria
The price is ₹5,863
₹6,688 total
20 Nov - 21 Nov
Unipark by Oro Verde Hotels
A swimming pool with a tiled deck, surrounded by buildings with large windows and a balcony.

9. Hotel Patrimonial by Greenfield

Hotel Patrimonial by Greenfield
3.5 star property
Downtown Guayaquil, 1.4 km from Puerto Santa Ana
8.4 out of 10, Very good, (169 reviews)
"Was ok"
United States
Juan
The price is ₹3,832
₹3,927 total
4 Nov - 5 Nov
Hotel Patrimonial by Greenfield
A modern bathroom with a glass shower enclosure, a marble sink, and a towel rack.

10. Fortune Hotel

Fortune Hotel
3.0 star property
River City, 1 km from Puerto Santa Ana
8.0 out of 10, Very good, (11 reviews)
"Is a great place the only problem is the disco bars outside the hotel "
United States
MARIA
The price is ₹3,805
₹3,900 total
6 Nov - 7 Nov
Fortune Hotel
A breakfast bar with a variety of food items and beverages, including a fruit juice dispenser and a coffee machine.

11. Grand Hotel Guayaquil, Centro Histórico.

Grand Hotel Guayaquil, Centro Histórico.
4.0 star property
Rocafuerte, 2.2 km from Puerto Santa Ana
9.2 out of 10, Wonderful, (1,002 reviews)
"Great location, great breakfast buffet, adjacent to Iguana park, not far from airport."
Canada
Victor
The price is ₹7,141
₹7,997 total
28 Nov - 29 Nov
Grand Hotel Guayaquil, Centro Histórico.
An outdoor seating area with tables and chairs, potted plants, and a view of trees through large windows.

12. Ibis Styles El Malecon Guayaquil

Ibis Styles El Malecon Guayaquil
4.0 star property
Downtown Guayaquil, 1.7 km from Puerto Santa Ana
9.4 out of 10, Exceptional, (357 reviews)
"Nice restaurant. Great location. Room was a good place to rest."
United States
Hector
The price is ₹5,697
₹6,409 total
6 Nov - 7 Nov
Ibis Styles El Malecon Guayaquil
A modern hotel lobby with a reception desk, seating area, and a large decorative plant.

13. Courtyard by Marriott Guayaquil

Courtyard by Marriott Guayaquil
3.5 star property
Kennedy, 2.5 km from Puerto Santa Ana
9.0 out of 10, Wonderful, (1,004 reviews)
"Great locations and wonderful staff.!!"
Canada
Carlos
The price is ₹7,691
₹8,603 total
13 Nov - 14 Nov
Courtyard by Marriott Guayaquil
A reception desk with a marble top and a modern light fixture above it.

14. TRYP by Wyndham Guayaquil Airport

TRYP by Wyndham Guayaquil Airport
4.5 star property
Simón Bolívar, 2.8 km from Puerto Santa Ana
9.0 out of 10, Wonderful, (1,007 reviews)
"Convenient near airport."
United States
MIGUEL A.
The price is ₹8,546
₹9,638 total
15 Nov - 16 Nov
TRYP by Wyndham Guayaquil Airport
A hotel lobby with a modern design, featuring a reception desk, seating area, and decorative columns.

15. Hotel Palace Guayaquil

Hotel Palace Guayaquil
4.0 star property
Rocafuerte, 1.9 km from Puerto Santa Ana
9.2 out of 10, Wonderful, (966 reviews)
"We have stayed at this hotel several times and it is consistently a good experience. Comfortable bed, good air conditioning, restaurant on site, farmacia nearby. The breakfast buffet is especially good."
United States
Bethany
The price is ₹5,465
₹6,154 total
21 Nov - 22 Nov
Hotel Palace Guayaquil
A high-rise hotel interior with multiple floors, large windows, and modern lighting fixtures.

16. Hilton Colon Guayaquil

Hilton Colon Guayaquil
4.5 star property
Kennedy, 3.2 km from Puerto Santa Ana
8.8 out of 10, Excellent, (1,004 reviews)
"Really easy to make the reservacion and chek in. Good service"
United States
SILVIA
The price is ₹9,524
₹10,714 total
29 Nov - 30 Nov
Hilton Colon Guayaquil
A modern living room with a sectional sofa, a yellow armchair, and a wooden coffee table.

17. Radisson Hotel Guayaquil

Radisson Hotel Guayaquil
5.0 star property
Kennedy, 2.9 km from Puerto Santa Ana
9.4 out of 10, Exceptional, (758 reviews)
"Very helpful and accommodating airport shuttle service."
United States
Jerry
The price is ₹8,067
₹9,110 total
6 Nov - 7 Nov
Radisson Hotel Guayaquil
A person in a swimsuit and red hat sitting on a green inflatable ring in a pool.

18. Oro Verde Guayaquil

Oro Verde Guayaquil
5.0 star property
Downtown Guayaquil, 2.1 km from Puerto Santa Ana
9.6 out of 10, Exceptional, (1,004 reviews)
"Very friendly staff, excellent breakfast, maintained and modern rooms. Was a great stay."
United States
ricardo
The price is ₹7,945
₹9,055 total
4 Dec - 5 Dec
Oro Verde Guayaquil
A person sitting by a window with a towel on their head, reading a magazine.

19. Holiday Inn Guayaquil Airport by IHG

Holiday Inn Guayaquil Airport by IHG
3.5 star property
3.7 km from Puerto Santa Ana
9.6 out of 10, Exceptional, (1,002 reviews)
"As close to the airport as you would want to be. No noise, and the pool and hot tube is great after a long travel time."
United States
Frederick
The price is ₹9,970
₹11,205 total
8 Nov - 9 Nov
Holiday Inn Guayaquil Airport by IHG
A bedroom with a large bed, a desk, a chair, and a mural on the wall.

20. HOTEL PERLA CENTRAL MALECON

HOTEL PERLA CENTRAL MALECON
2.5 star property
Downtown Guayaquil, 1.3 km from Puerto Santa Ana
7.2 out of 10, Good, (30 reviews)
"Great location and friendly staff. We had a great stay."
Australia
Ashleigh
The price is ₹2,989
₹2,989 total
17 Nov - 18 Nov
HOTEL PERLA CENTRAL MALECON
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Compare popular hotels in Puerto Santa Ana

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet-friendly
WiFi included
A modern living room with a large window, a flat-screen TV, a sofa, and a coffee table.
Wyndham Guayaquil Puerto Santa Ana
4.5 star property
9.4
Exceptional
1,003 reviews
View
A rooftop pool with a view of the city skyline.
Luxury Suites Riverfront GYE
3.5 star property
9.4
Exceptional
112 reviews
View
A laptop on a glass table with a plate of food and a chair in a room with a view of the sea.
River View suites Puerto Santa Ana gye
3.0 star property
9.0
Wonderful
67 reviews
View
A rooftop pool with a curved edge, lounge chairs, and potted plants.
Hotel Río Guayas by Art Hotels Ecuador
4.0 star property
10.0
Exceptional
5 reviews
View
A hotel lobby with a sofa, bookshelves, a coffee table, and a colorful mural of parrots.
Hostal Macaw
3.0 star property
10.0
Exceptional
11 reviews
View

Where to stay in Puerto Santa Ana

Find the best Puerto Santa Ana areas for the activities you enjoy most.
A row of colorful colonial buildings with balconies and wooden shutters.

Ecuador

Ecuador might not have many top sights, but C.C. Riocentro Sur and Mall del Sur are two attractions nearby that you can check out.

A colorful outdoor installation with large letters spelling out a word.
Photo by Botak Jon
Open Photo by Botak Jon

Downtown Guayaquil

Travellers come to Downtown Guayaquil for its abundant dining options, and you can see top attractions like Sports Federation of Guayas and Artisan Market while you're in town.

A lizard on a metal fence.

Kennedy

Unique features of Kennedy include the shopping and restaurants. Make a stop by San Marino Mall or World Trade Center while you're exploring the area.

A cityscape with a prominent skyscraper, a river, and a bridge.

Simón Bolívar

When in Simón Bolívar, you can plan a visit to Mall del Sol Shopping Center and San Marino Mall, some noteworthy sights in the nearby area.

Top Puerto Santa Ana Hotel Reviews

Hilton Colon Guayaquil

Hilton Colon Guayaquil

10/10 Excellent
"Beautful propery n location!"
James 1-night trip
Posted 13 hours ago
Hilton Colon Guayaquil

Frequently asked questions

What's it like in Puerto Santa Ana?
Puerto Santa Ana is a welcoming neighbourhood that travellers like for its restaurants and sporting events.
Where is the best hotel for a stay in Puerto Santa Ana?
Based on our traveller data, Wyndham Guayaquil Puerto Santa Ana is one of the top choices for your stay in Puerto Santa Ana. This hotel offers a full-service spa and 2 restaurants. Another good choice for your stay in the area is Luxury Suites Riverfront GYE.
How many hotels should I expect to find in Puerto Santa Ana?
If you're searching for places to stay in Guayaquil, Expedia has something to meet your needs with 88 Puerto Santa Ana hotels and other accommodation options to choose from.
If I need to cancel my hotel reservation in Puerto Santa Ana, will I receive a refund?
Yes, most room reservations are fully refundable provided that you cancel prior to the accommodation's cancellation deadline, which often is within 24-48 hours of your scheduled arrival. If your reservation is non-refundable, it may still be possible to cancel it and be given a refund within 24 hours of your booking. Plug in your dates, click on "Search", then filter by "fully refundable" to view the best deals in Puerto Santa Ana.
What is there to do around this Guayaquil neighbourhood?
Emporium by The Point, Santa Ana Garden and Santa Ana Hill are just a few of the places to visit in and around Puerto Santa Ana. While you're out sightseeing, Numa Pompilio Llona Street and El Carmen Hill are a couple of additional sights to visit in Guayaquil.