A calm river with clear water, surrounded by dense trees and rocky banks.

O Brien Hotels from โ‚น5,008

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Check prices for these dates

Tonight
23 Oct - 24 Oct
Tomorrow
24 Oct - 25 Oct
This weekend
23 Oct - 25 Oct
Next weekend
30 Oct - 1 Nov

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Our top choices for O Brien hotels

A La Quinta hotel with a modern facade, multiple windows, and a well-lit entrance.
A modern kitchen area with a coffee station, including a coffee machine, cups, and a toaster.
A modern restaurant with a long counter, multiple seating options including red and yellow chairs, and a large window providing a view.
A hotel room with a large bed, a sofa, a desk, and a wall with a geometric pattern.

1. La Quinta Inn & Suite by Wyndham Lake City

La Quinta Inn & Suite by Wyndham Lake City
Lake City
United States
Jack
โ‚น8,961
โ‚น10,081 total
includes taxes & fees
25 Oct - 26 Oct
La Quinta Inn & Suite by Wyndham Lake City
A spacious living area with a grey sofa, a coffee table, and a TV stand.
A hotel room with two beds, a desk, a TV, and a large window with curtains.
A hotel entrance with a covered walkway, palm trees, and a clear sky.
A hotel room with a sofa, a small table, a lamp, and artwork on the wall.

2. Best Western Plus Lake City

Best Western Plus Lake City
Lake City
United States
Melissa
โ‚น7,597
โ‚น8,546 total
includes taxes & fees
15 Nov - 16 Nov
Best Western Plus Lake City
A hotel room with a gray sofa, a bed with white linens, a desk with a chair, and a window with blinds.
A modern hotel lobby with a fireplace, seating areas, and a bar.
A modern living room with a sectional sofa, a round coffee table, a hanging chair, and a flat-screen TV on a glass stand.
Exterior

3. Comfort Suites Lake City

Comfort Suites Lake City
Lake City
United States
Brooke
โ‚น9,814
โ‚น11,040 total
includes taxes & fees
1 Nov - 2 Nov
Comfort Suites Lake City
A self-service beverage station with a variety of drinks, snacks, and a refrigerated section.
An outdoor patio with a stone fire feature, blue cushioned seating, and a grill.
A modern hotel lobby with a central counter displaying snacks and beverages, two digital screens above the counter, and a seating area with a view of the lobby.
A modern interior with two red chairs and a small table, large windows, and hanging pendant lights.

4. Tru by Hilton Lake City

Tru by Hilton Lake City
Lake City
United States
Carlos
โ‚น9,957
โ‚น11,202 total
includes taxes & fees
25 Oct - 26 Oct
Tru by Hilton Lake City
Lobby
Room
Pool
Snack bar

5. Hampton Inn & Suites Lake City

Hampton Inn & Suites Lake City
Lake City
United States
James
โ‚น9,945
โ‚น11,189 total
includes taxes & fees
25 Oct - 26 Oct
Hampton Inn & Suites Lake City
An indoor swimming pool with clear water, surrounded by glass doors and windows, and a wooden deck area.
A modern living room with two green sofas, a white coffee table, and a flat-screen TV mounted on the wall.
An outdoor patio area with a sectional sofa, chairs, a coffee table, and a fire pit.
A modern lounge area with a fireplace, comfortable seating, a dining table, and a large window offering a view.

6. Fairfield Inn & Suites Lake City

Fairfield Inn & Suites Lake City
Lake City
United States
Anthony
โ‚น8,885
โ‚น9,995 total
includes taxes & fees
29 Oct - 30 Oct
Fairfield Inn & Suites Lake City
A picnic table with a potted plant, located in a grassy area with a tree and a road in the background.
A living room with a black leather sofa, a wooden coffee table with a plant, and framed pictures on the wall.
A hotel lobby with a view of the street, a reception desk, and a large map on the wall.
A hotel lobby with a reception desk, a clock, a plant, a water dispenser, and a coffee station.

7. Americas Best Value Inn Lake City

Americas Best Value Inn Lake City
Lake City
United States
Sara
โ‚น6,717
โ‚น7,558 total
includes taxes & fees
26 Oct - 27 Oct
Americas Best Value Inn Lake City
An outdoor patio with a stone fire pit, grey cushioned seating, and wicker ottomans.
A modern hotel with a two-story structure, a covered outdoor seating area, and a parking lot with marked spaces.
A modern hotel lobby with a reception desk, seating areas, and a large screen.
A modern hotel room with a bed, a desk with a computer, a TV, and a lamp.

8. Home2 Suites by Hilton Lake City

Home2 Suites by Hilton Lake City
Lake City
United States
Laurie
โ‚น11,254
โ‚น12,660 total
includes taxes & fees
1 Nov - 2 Nov
Home2 Suites by Hilton Lake City
A multi-story hotel with a modern design, featuring a prominent entrance and a parking area.
A reception area with two wooden reception desks, a wall-mounted decorative piece, and a refrigerator stocked with beverages.
A modern restaurant with round tables and yellow chairs, a bar area with a TV, and a menu display.
Lobby

9. Courtyard By Marriott Lake City

Courtyard By Marriott Lake City
Lake City
United States
Angel
โ‚น11,009
โ‚น12,385 total
includes taxes & fees
1 Nov - 2 Nov
Courtyard By Marriott Lake City
An outdoor patio area with wicker chairs, a round table, and a fire pit.
A modern interior with a dark wood desk, a blue chair, a sofa, and a patterned rug.
A modern interior with a sofa, round tables, and chairs, a TV mounted on the wall, and a patterned wall.
A modern interior with a central kitchen area, a seating area with a sofa and chairs, and a large window providing natural light.

10. TownePlace Suites by Marriott Lake City

TownePlace Suites by Marriott Lake City
Lake City
United States
John
โ‚น12,186
โ‚น13,710 total
includes taxes & fees
25 Oct - 26 Oct
TownePlace Suites by Marriott Lake City
A hotel lobby with multiple seating areas, including round tables and booths, and a high ceiling with recessed lighting.
A hotel room with two beds, a TV, a desk with a lamp, and a window with blinds.
A gym with treadmills, weight machines, and dumbbells.
A multi-story hotel with a prominent 'Holiday Inn' sign, balconies, and a palm tree.

11. Holiday Inn & Suites Lake City by IHG

Holiday Inn & Suites Lake City by IHG
Lake City
United States
C.jeffery
โ‚น9,008
โ‚น10,135 total
includes taxes & fees
22 Nov - 23 Nov
Holiday Inn & Suites Lake City by IHG
A modern restaurant with a central counter, red chairs, and a blue and white color scheme.
A hotel with a covered entrance, a sign indicating it is a Holiday Inn Express, and a well-maintained lawn area.
A reception area with a counter, seating, and a fireplace.
A conference room with a stone fireplace, a flat-screen TV, and two office chairs.

12. Holiday Inn Express & Suites Live Oak by IHG

Holiday Inn Express & Suites Live Oak by IHG
Live Oak
United States
Tammy
โ‚น10,431
โ‚น11,474 total
includes taxes & fees
15 Nov - 16 Nov
Holiday Inn Express & Suites Live Oak by IHG
A spacious lobby with a high ceiling, a large window, a dining area with green chairs, and a black door leading outside.
A white building with multiple windows and a sign that reads 'Quality Inn.'
A hotel room with two beds, a desk, a chair, a painting on the wall, and a patterned carpet.
A reception area with a counter, a coffee machine, and a potted plant.

13. Quality Inn Lake City

Quality Inn Lake City
Lake City
United States
Dawn
โ‚น7,174
โ‚น8,070 total
includes taxes & fees
22 Nov - 23 Nov
Quality Inn Lake City
A hotel room with a large bed, a desk with a computer, a television, and a window with curtains.
An aerial view of a hotel with a swimming pool, parking lot, and surrounding greenery.
A restaurant with a yellow accent wall, white tiled floor, and black and blue chairs.
Lobby

14. Super 8 by Wyndham Lake City

Super 8 by Wyndham Lake City
Lake City
United States
Scott
โ‚น5,884
โ‚น6,619 total
includes taxes & fees
15 Nov - 16 Nov
Super 8 by Wyndham Lake City
A hotel room with two beds, a TV, a desk, and a painting of a sunset.
A hotel room with a large bed, a bedside table, a nightstand, a window, and a bathroom with a toilet and sink.
A kitchen with a black refrigerator and a microwave on a wooden shelf.
A swimming pool with lounge chairs, a small pool house, and a yellow multi-story building with balconies.

15. Days Inn by Wyndham Lake City I-75

Days Inn by Wyndham Lake City I-75
Lake City
United States
Nathan
โ‚น6,979
โ‚น7,852 total
includes taxes & fees
25 Oct - 26 Oct
Days Inn by Wyndham Lake City I-75
A covered outdoor area with a paved walkway, benches, and potted plants.
A compact kitchen with a blue refrigerator, a black coffee maker, a microwave, and a small black refrigerator.
A compact RV kitchen with wooden cabinets, a microwave, a stove, and a sink.
A grassy area with a picnic table, a car parked in front of a building with a sloped roof, and trees with hanging moss.

16. Cindys Motel

Cindys Motel
Mayo
United States
Diane
โ‚น7,822
โ‚น8,453 total
includes taxes & fees
23 Nov - 24 Nov
Cindys Motel
A reception area with a stone wall, a blue accent wall, a clock, and a window with a view of the parking lot.
A modern bedroom with a wooden headboard, two bedside lamps, a patterned bedspread, and a blue door.
A bathroom with a towel rack, a shower curtain, and a toilet.
Two doors, one blue and one green, with numbers 105 and 103 respectively, against a brick wall.

17. Regal Inn

Regal Inn
Lake City
United States
Gerardo
โ‚น5,275
โ‚น5,934 total
includes taxes & fees
2 Nov - 3 Nov
Regal Inn
An aerial view of a campground with RVs, a swimming pool, and tennis courts.
A serene lakeside campsite with picnic tables and chairs.
A wooden cabin with a kitchen, a bathroom, and a loft bedroom.
A wooden cabin with a porch, a front door, and a small window.

18. Suwannee River Rendezvous

Suwannee River Rendezvous
Mayo
United States
Beth
โ‚น8,502
โ‚น11,398 total
includes taxes & fees
9 Nov - 10 Nov
Suwannee River Rendezvous
A modern kitchen with a large window, a flat-screen TV, and a coffee machine.
A hotel lobby with a dining area, a reception desk, and a view of the outside.
A reception area with a tiled counter, a computer, a sign reading 'Quality,' and two decorative vases.
A hotel with a swimming pool, white lounge chairs, and a fenced area.

19. Quality Inn White Springs Suwanee

Quality Inn White Springs Suwanee
White Springs
United States
Pennee
โ‚น6,258
โ‚น6,883 total
includes taxes & fees
15 Nov - 16 Nov
Quality Inn White Springs Suwanee
A hotel reception area with a reception desk, seating area, and a view of the parking lot.
A dining area with wooden chairs and tables, a coffee machine, and a counter with various items.
A compact room with a flat-screen TV on a wooden cabinet, a microwave on a small black stand, a chair, and a mirror with a light above it.
A reception area with a wooden floor, a reception desk, a seating area with chairs, and a view through the glass doors to the outside.

20. Econo Lodge Live Oak

Econo Lodge Live Oak
Live Oak
United States
Alexia
โ‚น8,257
โ‚น9,081 total
includes taxes & fees
2 Nov - 3 Nov
Econo Lodge Live Oak
View all properties

Hotels recommended for families in O Brien

A La Quinta hotel with a modern facade, multiple windows, and a well-lit entrance.
A modern kitchen area with a coffee station, including a coffee machine, cups, and a toaster.
A modern restaurant with a long counter, multiple seating options including red and yellow chairs, and a large window providing a view.
A hotel room with a large bed, a sofa, a desk, and a wall with a geometric pattern.

La Quinta Inn & Suite by Wyndham Lake City

La Quinta Inn & Suite by Wyndham Lake City
Lake City
โ‚น8,961
โ‚น10,081 total
includes taxes & fees
25 Oct - 26 Oct
La Quinta Inn & Suite by Wyndham Lake City
A spacious living area with a grey sofa, a coffee table, and a TV stand.
A hotel room with two beds, a desk, a TV, and a large window with curtains.
A hotel entrance with a covered walkway, palm trees, and a clear sky.
A hotel room with a sofa, a small table, a lamp, and artwork on the wall.

Best Western Plus Lake City

Best Western Plus Lake City
Lake City
โ‚น7,597
โ‚น8,546 total
includes taxes & fees
15 Nov - 16 Nov
Best Western Plus Lake City
A hotel room with a gray sofa, a bed with white linens, a desk with a chair, and a window with blinds.
A modern hotel lobby with a fireplace, seating areas, and a bar.
A modern living room with a sectional sofa, a round coffee table, a hanging chair, and a flat-screen TV on a glass stand.
Exterior

Comfort Suites Lake City

Comfort Suites Lake City
Lake City
โ‚น9,814
โ‚น11,040 total
includes taxes & fees
1 Nov - 2 Nov
Comfort Suites Lake City
A self-service beverage station with a variety of drinks, snacks, and a refrigerated section.
An outdoor patio with a stone fire feature, blue cushioned seating, and a grill.
A modern hotel lobby with a central counter displaying snacks and beverages, two digital screens above the counter, and a seating area with a view of the lobby.
A modern interior with two red chairs and a small table, large windows, and hanging pendant lights.

Tru by Hilton Lake City

Tru by Hilton Lake City
Lake City
โ‚น9,957
โ‚น11,202 total
includes taxes & fees
25 Oct - 26 Oct
Tru by Hilton Lake City
Lobby
Room
Pool
Snack bar

Hampton Inn & Suites Lake City

Hampton Inn & Suites Lake City
Lake City
โ‚น9,945
โ‚น11,189 total
includes taxes & fees
25 Oct - 26 Oct
Hampton Inn & Suites Lake City
An indoor swimming pool with clear water, surrounded by glass doors and windows, and a wooden deck area.
A modern living room with two green sofas, a white coffee table, and a flat-screen TV mounted on the wall.
An outdoor patio area with a sectional sofa, chairs, a coffee table, and a fire pit.
A modern lounge area with a fireplace, comfortable seating, a dining table, and a large window offering a view.

Fairfield Inn & Suites Lake City

Fairfield Inn & Suites Lake City
Lake City
โ‚น8,885
โ‚น9,995 total
includes taxes & fees
29 Oct - 30 Oct
Fairfield Inn & Suites Lake City
A picnic table with a potted plant, located in a grassy area with a tree and a road in the background.
A living room with a black leather sofa, a wooden coffee table with a plant, and framed pictures on the wall.
A hotel lobby with a view of the street, a reception desk, and a large map on the wall.
A hotel lobby with a reception desk, a clock, a plant, a water dispenser, and a coffee station.

Americas Best Value Inn Lake City

Americas Best Value Inn Lake City
Lake City
โ‚น6,717
โ‚น7,558 total
includes taxes & fees
26 Oct - 27 Oct
Americas Best Value Inn Lake City
An outdoor patio with a stone fire pit, grey cushioned seating, and wicker ottomans.
A modern hotel with a two-story structure, a covered outdoor seating area, and a parking lot with marked spaces.
A modern hotel lobby with a reception desk, seating areas, and a large screen.
A modern hotel room with a bed, a desk with a computer, a TV, and a lamp.

Home2 Suites by Hilton Lake City

Home2 Suites by Hilton Lake City
Lake City
โ‚น11,254
โ‚น12,660 total
includes taxes & fees
1 Nov - 2 Nov
Home2 Suites by Hilton Lake City
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Learn more about O Brien

Escape to this rural Florida gem where the Suwannee River offers peaceful kayaking trips and fishing adventures. Nearby Spirit of the Suwannee Music Park hosts live concerts, while O'Brien's local farms welcome visitors for fresh produce and family-friendly activities.

See all hotels in O Brien
A calm river surrounded by trees reflecting in the water.

Top O Brien Hotel Reviews

Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

10/10 Excellent
"Nice accommodations at a fair price."
Steven 1-night trip
Posted 13 hours ago
Holiday Inn Express & Suites Alachua - Gainesville Area by IHG
Comfort Suites Lake City

Comfort Suites Lake City

10/10 Excellent
"This hotel was one of the best I have stayed at in a long time! Extremely clean, quiet, and felt safe for my family. The breakfast staff was so friendly and took such good care of us! We will definitely stay here again!"
Megan 1-night trip
Posted 15 hours ago
Comfort Suites Lake City
Hampton Inn & Suites Lake City

Hampton Inn & Suites Lake City

10/10 Excellent
"Nice new property and helpful staff. The outside pool was nice to be outside and relax. Lots of different seating. Rooms were nicely decorated and very comfortable."
Paul 1-night trip
Posted 19 hours ago
Hampton Inn & Suites Lake City
Quality Inn & Suites Live Oak I-10 Exit 283

Quality Inn & Suites Live Oak I-10 Exit 283

8/10 Good
"Room was clean the TV didn't work would turn on but couldn't watch anything"
Brittany 1-night trip
Posted 3 days ago
Quality Inn & Suites Live Oak I-10 Exit 283
Fairfield Inn & Suites Lake City

Fairfield Inn & Suites Lake City

10/10 Excellent
"Great place! Very clean. Awesome breakfast."
Kevin 1-night trip
Posted 3 days ago
Fairfield Inn & Suites Lake City
Baymont by Wyndham Lake City I-75

Baymont by Wyndham Lake City I-75

10/10 Excellent
"Loved the staff very quiet"
Sierra 1-night trip
Posted 3 days ago
Baymont by Wyndham Lake City I-75
Courtyard By Marriott Lake City

Courtyard By Marriott Lake City

8/10 Good
"Quiet."
Aurel 1-night trip
Posted 4 days ago
Courtyard By Marriott Lake City
Holiday Inn Express & Suites Live Oak by IHG

Holiday Inn Express & Suites Live Oak by IHG

10/10 Excellent
"The room was very clean and comfortable, and the staff was great."
Linda 2-night trip
Posted 5 days ago
Holiday Inn Express & Suites Live Oak by IHG
Americas Best Value Inn Lake City

Americas Best Value Inn Lake City

10/10 Excellent
"Very Clem"
Anicia 1-night trip
Posted 6 days ago
Americas Best Value Inn Lake City

More cheap stays in O Brien

Quality Inn Lake City

Quality Inn Lake City

285 Sw Commerce Dr Lake City FL
โ‚น7,174
โ‚น8,070 total
22 Nov - 23 Nov
includes taxes & fees
Quality Inn Lake City
Best Western Plus Lake City

Best Western Plus Lake City

350 SW Florida Gateway Dr Lake City FL
โ‚น7,597
โ‚น8,546 total
15 Nov - 16 Nov
includes taxes & fees
Best Western Plus Lake City
Quality Inn & Suites Live Oak I-10 Exit 283

Quality Inn & Suites Live Oak I-10 Exit 283

6819 Us Highway 129 Live Oak FL
โ‚น8,670
โ‚น9,537 total
2 Nov - 3 Nov
includes taxes & fees
7/10 Good! (598 reviews)
Quality Inn & Suites Live Oak I-10 Exit 283
Comfort Suites Lake City

Comfort Suites Lake City

3690 W Us Highway 90 Lake City FL
โ‚น9,814
โ‚น11,040 total
1 Nov - 2 Nov
includes taxes & fees
9.4/10 Exceptional! (1,001 reviews)
Comfort Suites Lake City
Hampton Inn & Suites Lake City

Hampton Inn & Suites Lake City

450 SW Florida Gateway Drive Lake City FL
โ‚น9,945
โ‚น11,189 total
25 Oct - 26 Oct
includes taxes & fees
9.4/10 Exceptional! (1,001 reviews)
Hampton Inn & Suites Lake City
Tru by Hilton Lake City

Tru by Hilton Lake City

284 NW Centurion Court Lake City FL
โ‚น9,957
โ‚น11,202 total
25 Oct - 26 Oct
includes taxes & fees
Tru by Hilton Lake City

Frequently asked questions

Where is the best place to stay in O Brien?
La Quinta Inn & Suite by Wyndham Lake City, located 18.2 mi (29.3 km) from the heart of O Brien, is a top choice for your stay, based on our traveller data. Two other options for your trip to the area are Holiday Inn Express & Suites Alachua - Gainesville Area by IHG and Postcard Cabins Gilchrist Springs, Outdoor Collection by Marriott Bonvoy. See all available top hotels, or vacation rentals in O Brien.
If I need to cancel my hotel reservation in O Brien, will I receive a refund?
Yes! You'll find that most hotel bookings are refundable if you cancel before the hotel's cancellation deadline, which is usually within 24-48 hours of the scheduled arrival. If your reservation is non-refundable, you might be able to still cancel and receive a refund within 24 hours of booking. Filter your search by fully refundable to find flexible hotel deals in O Brien.
What are some accommodation options with pools in O Brien?
La Quinta Inn & Suite by Wyndham Lake City: Provides buffet, an indoor pool and free self parking. Holiday Inn Express & Suites Alachua - Gainesville Area by IHG and Best Western Plus Lake City are two additional hotels that feature an on-site pool. View all hotels with pools in O Brien.
How is it to stay in O Brien?
Visitors to O Brien will definitely find plenty to explore and enjoy. In O Brien, there are 9 hotels and other accommodation options to choose from. Find out more about O Brien.
What are the top places to visit in O Brien?
Natural beauty is on display at Suwannee River, Ichetucknee River and Ichetucknee Springs State Park. You'll also find Lafayette Blue Springs State Park and Lake City Mall in the area. Take a look at what more there is to see and do in Expedia's O Brien guide.
What's the seasonal weather in O Brien?
The hottest months are usually July and August, with an average temperature of 27ยฐC, while the coldest months are January and February, with an average of 14ยฐC. Average annual precipitation for O Brien is 1278 mm.

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