A calm river with clear water, surrounded by dense trees and rocky banks.

O Brien Hotels from ā‚¹6,055

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Check prices for these dates

This weekend
24 Jul - 26 Jul
Next weekend
31 Jul - 2 Aug

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Our top choices for O Brien hotels

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1. Best Western Plus Lake City

Best Western Plus Lake City
2.5 star property
Lake City
9.0 out of 10, Wonderful, (1,069 reviews)
"Nice room and great breakfast."
United States
James
The price is ā‚¹8,691
ā‚¹9,778 total
includes taxes & fees
2 Aug - 3 Aug
Best Western Plus Lake City
Exterior

2. La Quinta Inn & Suite by Wyndham Lake City

La Quinta Inn & Suite by Wyndham Lake City
3.0 star property
Lake City
8.8 out of 10, Excellent, (1,140 reviews)
"Great stay"
United States
Priscilla J
The price is ā‚¹8,518
ā‚¹9,582 total
includes taxes & fees
2 Aug - 3 Aug
La Quinta Inn & Suite by Wyndham Lake City
Snack bar

3. Tru by Hilton Lake City

Tru by Hilton Lake City
2.5 star property
Lake City
9.2 out of 10, Wonderful, (1,004 reviews)
"Clean Rooms excellent staff good breakfast"
United States
James
The price is ā‚¹9,684
ā‚¹10,894 total
includes taxes & fees
2 Aug - 3 Aug
Tru by Hilton Lake City
Outdoor pool, open 9:00 AM to 10:00 PM, pool loungers

4. Hampton Inn & Suites Lake City

Hampton Inn & Suites Lake City
2.5 star property
Lake City
9.4 out of 10, Exceptional, (1,002 reviews)
"Room was clean and breakfast was great!!!"
United States
Justo
The price is ā‚¹10,043
ā‚¹11,299 total
includes taxes & fees
2 Aug - 3 Aug
Hampton Inn & Suites Lake City
Suite, Multiple Beds, Accessible, Non Smoking | Pillow-top beds, desk, laptop workspace, iron/ironing board

5. Comfort Suites Lake City

Comfort Suites Lake City
2.5 star property
Lake City
9.4 out of 10, Exceptional, (1,000 reviews)
"Great place to stop for the night, very clean and great breakfast"
United States
RAFI
The price is ā‚¹9,473
ā‚¹10,657 total
includes taxes & fees
4 Aug - 5 Aug
Comfort Suites Lake City
Down duvets, pillow-top beds, blackout curtains, free WiFi

6. Super 8 by Wyndham Lake City

Super 8 by Wyndham Lake City
2.0 star property
Lake City
7.4 out of 10, Good, (740 reviews)
"Comfortable beds, quiet, nice staff."
United States
Mari
The price is ā‚¹6,299
ā‚¹7,086 total
includes taxes & fees
19 Aug - 20 Aug
Super 8 by Wyndham Lake City
Free daily buffet breakfast

7. Holiday Inn Express & Suites Live Oak by IHG

Holiday Inn Express & Suites Live Oak by IHG
2.5 star property
Live Oak
8.4 out of 10, Very good, (855 reviews)
"Great stay!"
United States
Wes
The price is ā‚¹9,754
ā‚¹10,729 total
includes taxes & fees
2 Aug - 3 Aug
Holiday Inn Express & Suites Live Oak by IHG
Terrace/patio

8. Home2 Suites by Hilton Lake City

Home2 Suites by Hilton Lake City
3.0 star property
Lake City
9.4 out of 10, Exceptional, (804 reviews)
"Great place to stay we will be back soon. "
United States
William
The price is ā‚¹11,816
ā‚¹13,294 total
includes taxes & fees
9 Aug - 10 Aug
Home2 Suites by Hilton Lake City
BBQ/picnic Area

9. Americas Best Value Inn Lake City

Americas Best Value Inn Lake City
2.0 star property
Lake City
8.6 out of 10, Excellent, (1,000 reviews)
"Staff was friendly the room was clean."
United States
Lorena
The price is ā‚¹5,910
ā‚¹6,649 total
includes taxes & fees
26 Jul - 27 Jul
Americas Best Value Inn Lake City
Pillow-top beds, in-room safe, desk, blackout curtains

10. Days Inn by Wyndham Lake City I-75

Days Inn by Wyndham Lake City I-75
2.0 star property
Lake City
7.6 out of 10, Good, (1,000 reviews)
"Great for a short stay and clean"
United States
Brizheet
The price is ā‚¹6,103
ā‚¹6,866 total
includes taxes & fees
26 Jul - 27 Jul
Days Inn by Wyndham Lake City I-75
Lobby

11. Quality Inn White Springs Suwanee

Quality Inn White Springs Suwanee
2.5 star property
White Springs
7.2 out of 10, Good, (687 reviews)
"Cheap and food enough"
United States
william
The price is ā‚¹5,505
ā‚¹6,055 total
includes taxes & fees
26 Jul - 27 Jul
Quality Inn White Springs Suwanee
Indoor pool

12. Fairfield Inn & Suites Lake City

Fairfield Inn & Suites Lake City
3.0 star property
Lake City
9.0 out of 10, Wonderful, (257 reviews)
The price is ā‚¹10,307
ā‚¹11,596 total
includes taxes & fees
5 Aug - 6 Aug
Fairfield Inn & Suites Lake City
Lobby sitting area

13. Motel 6 ā€“ Lake City, Fl ā€“ Medical Center

Motel 6 ā€“ Lake City, Fl ā€“ Medical Center
2.0 star property
Lake City
7.6 out of 10, Good, (215 reviews)
"Amazing stay"
United States
Pennee
The price is ā‚¹5,596
ā‚¹6,296 total
includes taxes & fees
26 Jul - 27 Jul
Motel 6 ā€“ Lake City, Fl ā€“ Medical Center
Outdoor spa tub

14. Baymont by Wyndham Lake City I-75

Baymont by Wyndham Lake City I-75
2.5 star property
Lake City
5.0 out of 10, (1,003 reviews)
"Desk & housekeeping staff were super helpful & friendly!"
United States
Cameron
The price is ā‚¹5,582
ā‚¹6,280 total
includes taxes & fees
26 Jul - 27 Jul
Baymont by Wyndham Lake City I-75
Lobby

15. Quality Inn Lake City

Quality Inn Lake City
2.5 star property
Lake City
8.0 out of 10, Very good, (1,002 reviews)
"Great breakfast; clean rooms; very friendly staff."
United States
Lucille
The price is ā‚¹7,388
ā‚¹8,311 total
includes taxes & fees
3 Aug - 4 Aug
Quality Inn Lake City
Lobby

16. Regal Inn

Regal Inn
2.5 star property
Lake City
8.4 out of 10, Very good, (611 reviews)
"First I was not sure if we wanted to stay there, but our room was pretty nice, price was excellent every thing was very clean. Lady at the front desk was very nice."
United States
Samuel
The price is ā‚¹5,971
ā‚¹6,717 total
includes taxes & fees
30 Jul - 31 Jul
Regal Inn
Lobby

17. Econo Lodge Live Oak

Econo Lodge Live Oak
2.0 star property
Live Oak
7.0 out of 10, Good, (314 reviews)
"The room was fairly cheap and staff was friendly."
United States
James
The price is ā‚¹7,064
ā‚¹7,770 total
includes taxes & fees
26 Jul - 27 Jul
Econo Lodge Live Oak
Exterior

18. Holiday Inn & Suites Lake City by IHG

Holiday Inn & Suites Lake City by IHG
3.0 star property
Lake City
8.6 out of 10, Excellent, (1,000 reviews)
"Breakfast was nice, friendly staff, convenient location. Clean room"
United States
Renee
The price is ā‚¹8,832
ā‚¹9,936 total
includes taxes & fees
9 Aug - 10 Aug
Holiday Inn & Suites Lake City by IHG
BBQ/picnic Area

19. Cindys Motel

Cindys Motel
2.5 star property
Mayo
8.8 out of 10, Excellent, (136 reviews)
"wonderful, quiet, a hide a way for a fun stay"
United States
Diane
The price is ā‚¹8,474
ā‚¹9,158 total
includes taxes & fees
26 Jul - 27 Jul
Cindys Motel
Desk, laptop workspace, iron/ironing board, free cots/infant beds

20. Days Inn by Wyndham Lake City I-10

Days Inn by Wyndham Lake City I-10
2.0 star property
Lake City
7.0 out of 10, Good, (1,005 reviews)
"Great place to stay"
United States
Serhii
The price is ā‚¹6,074
ā‚¹6,834 total
includes taxes & fees
29 Jul - 30 Jul
Days Inn by Wyndham Lake City I-10
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Learn more about O Brien

Escape to this rural Florida gem where the Suwannee River offers peaceful kayaking trips and fishing adventures. Nearby Spirit of the Suwannee Music Park hosts live concerts, while O'Brien's local farms welcome visitors for fresh produce and family-friendly activities.

See all hotels in O Brien
A calm river surrounded by trees reflecting in the water.

Top O Brien Hotel Reviews

Postcard Cabins Gilchrist Springs, Outdoor Collection by Marriott Bonvoy

Postcard Cabins Gilchrist Springs, Outdoor Collection by Marriott Bonvoy

10/10 Excellent
"Great experience at Postcard Cabins! We had a late arrival - pulling right up to the cabin and having the code couldnā€™t have been easier. A very special experience for the family waking up on a bunk bed in the woods!"
Amanda 1-night trip
Posted 7 hours ago
Postcard Cabins Gilchrist Springs, Outdoor Collection by Marriott Bonvoy

More cheap stays in O Brien

Baymont by Wyndham Lake City I-75

Baymont by Wyndham Lake City I-75

3598 W Us Highway 90 Lake City FL
The price is ā‚¹5,582 per night from 26 Jul to 27 Jul
ā‚¹5,582
ā‚¹6,280 total
26 Jul - 27 Jul
includes taxes & fees

Frequently asked questions

Where is the best place to stay in O Brien?
Holiday Inn Express & Suites Alachua - Gainesville Area by IHG, located 29.9 mi (48.2 km) from the heart of O Brien, is a top choice for your stay, based on our traveller data. Two other options for your trip to the area are Best Western Plus Lake City and La Quinta Inn & Suite by Wyndham Lake City. See all available top hotels, or vacation rentals in O Brien.
If I need to cancel my hotel reservation in O Brien, will I receive a refund?
Yes! You'll find that most hotel bookings are refundable if you cancel before the hotel's cancellation deadline, which is usually within 24-48 hours of the scheduled arrival. If your reservation is non-refundable, you might be able to still cancel and receive a refund within 24 hours of booking. Filter your search by fully refundable to find flexible hotel deals in O Brien.
What are some accommodation options with pools in O Brien?
Holiday Inn Express & Suites Alachua - Gainesville Area by IHG: Provides buffet, an outdoor pool and complimentary high-speed (wired) Internet access. Best Western Plus Lake City and La Quinta Inn & Suite by Wyndham Lake City are two additional hotels that feature an on-site pool. View all hotels with pools in O Brien.
How is it to stay in O Brien?
Visitors to O Brien will definitely find plenty to explore and enjoy. In O Brien, there are 9 hotels and other accommodation options to choose from. Find out more about O Brien.
What are the top places to visit in O Brien?
Natural beauty is on display at Suwannee River, Ichetucknee River and Ichetucknee Springs State Park. You'll also find Troy Spring State Park and Wes Skiles Peacock Springs State Park in the area. Take a look at what more there is to see and do in Expedia's O Brien guide.
What's the seasonal weather in O Brien?
The hottest months are usually July and August, with an average temperature of 27Ā°C, while the coldest months are January and February, with an average of 14Ā°C. Average annual precipitation for O Brien is 1278 mm.

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