O Brien Hotels from ₹5,718
Change your mind
Book hotels with free cancellation
Be picky
Search almost a million properties worldwide
Go beyond your typical stay in O Brien
Family friendly
Check prices for these dates
Top 10 O Brien hotels and places to stay

Holiday Inn Express & Suites Alachua - Gainesville Area by IHG
Holiday Inn Express & Suites Alachua - Gainesville Area by IHG
9.4 out of 10, Exceptional, (1000)
The price is ₹10,288
₹11,574 total
includes taxes & fees
23 Nov - 24 Nov

Americas Best Value Inn Alachua
Americas Best Value Inn Alachua
4.8 out of 10, (590)
The price is ₹5,905
₹6,643 total
includes taxes & fees
26 Oct - 27 Oct

La Quinta Inn & Suite by Wyndham Lake City
La Quinta Inn & Suite by Wyndham Lake City
8.8 out of 10, Excellent, (1000)
The price is ₹8,310
₹9,349 total
includes taxes & fees
26 Oct - 27 Oct

Hampton Inn & Suites Alachua I-75
Hampton Inn & Suites Alachua I-75
9.4 out of 10, Exceptional, (462)
The price is ₹8,528
₹9,594 total
includes taxes & fees
23 Nov - 24 Nov

Best Western Plus Lake City
Best Western Plus Lake City
9.2 out of 10, Wonderful, (1031)
The price is ₹7,091
₹7,977 total
includes taxes & fees
2 Nov - 3 Nov

Courtyard By Marriott Lake City
Courtyard By Marriott Lake City
9.6 out of 10, Exceptional, (156)
The price is ₹9,585
₹10,783 total
includes taxes & fees
26 Oct - 27 Oct
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in
Learn more about O Brien
Escape to this rural Florida gem where the Suwannee River offers peaceful kayaking trips and fishing adventures. Nearby Spirit of the Suwannee Music Park hosts live concerts, while O'Brien's local farms welcome visitors for fresh produce and family-friendly activities.

Top O Brien Hotel Reviews

Courtyard By Marriott Lake City
10/10 Excellent
More cheap stays in O Brien

Best Western Plus Lake City
350 SW Florida Gateway Dr, Lake City, FL
The price is ₹7,091 per night from 2 Nov to 3 Nov
₹7,091
₹7,977 total
2 Nov - 3 Nov
includes taxes & fees
9/10 Wonderful! (1,027 reviews)
Frequently asked questions
Explore a world of travel with Expedia
Accommodation near O Brien attractions
- Hotels near Ichetucknee Springs State Park
- Hotels near Ginnie Spring
- Hotels near Suwannee River State Park
- Hotels near Santa Fe River
- Hotels near Poe Springs Park
- Hotels near Florida Department of Transportation
- Hotels near Southside Sports Complex
- Hotels near Lake City Mall
- Hotels near Lake City Veterans Affairs Medical Center
- Hotels near North Florida Speedway
- Hotels near Columbia County Courthouse
Hotels Near O Brien, Florida
- Lake City Hotels
- Florida Panhandle Hotels
- Gulf Coast Hotels
- Live Oak Hotels
- High Springs Hotels
- Alachua Hotels
- Perry Hotels
- Newberry Hotels
- Madison Hotels
- Central West Coast Florida Hotels
- Old Town Hotels
- Jasper Hotels
- Southeastern United States Hotels
- Fort White Hotels
- Northern Florida Hotels
- Branford Hotels
- Mayo Hotels
- White Springs Hotels
- Trenton Hotels
- Day Hotels
Explore more hotels
- Americas Best Value Inn Lake City
- Baymont by Wyndham Lake City
- BlueGem Motel
- Days Inn by Wyndham Lake City I-75
- Motel 6 – Lake City, Fl – Medical Center
- Fairfield Inn & Suites Lake City
- Hampton Inn & Suites Alachua I-75
- Americas Best Value Inn Alachua
- Super 8 by Wyndham Lake City
- Home2 Suites by Hilton Lake City
More ways to book
Expedia's Latest Trends
General
- Visit St. Augustine
- Visit Cape Coral
- Visit Fort Myers Beach
- Visit Vero Beach
- Visit Panama City Beach
- Visit Melbourne Beach
- Visit Fort Walton Beach
- Visit Boca Raton
- Visit Tallahassee
- Visit Boynton Beach
- Visit Pensacola
- Visit West Palm Beach
- Visit Palm Beach
- Visit Orange City
- Visit Key West
- Visit Miramar Beach
- Visit Port Saint Lucie
- Visit Palm Beach Gardens
- Visit Cocoa Beach
- Visit Destin
- Visit Cape Canaveral