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Our top choices for Mississippi River hotels

The Eagles Nest Inn

The Eagles Nest Inn
3.0 star property
14.2 km from Mississippi River
9.4 out of 10, Exceptional, (19)
"The room was great. Large and attractive!! Nice bathroom. Had all the convenience you need from TV to mini frig. "
United States
Judith
The price is ₹9,449
₹10,728 total
includes taxes & fees
17 Dec - 18 Dec
The Eagles Nest Inn

Sleep Inn & Suites Hannibal West

Sleep Inn & Suites Hannibal West
2.5 star property
30.3 km from Mississippi River
9.6 out of 10, Exceptional, (1004)
"Great area"
United States
kelvin
The price is ₹9,146
₹10,596 total
includes taxes & fees
4 Jan - 5 Jan 2026
Sleep Inn & Suites Hannibal West

River's Edge Motel

River's Edge Motel
2.0 star property
13.6 km from Mississippi River
9.0 out of 10, Wonderful, (356)
"Excellent stay !!! Quite "
United States
Bradley
The price is ₹7,234
₹8,213 total
includes taxes & fees
22 Dec - 23 Dec
River's Edge Motel

Riverside Inn Hannibal

Riverside Inn Hannibal
2.5 star property
25.1 km from Mississippi River
9.4 out of 10, Exceptional, (165)
"Great place to stay!"
United States
Sandy
The price is ₹13,332
₹18,427 total
includes taxes & fees
20 Dec - 21 Dec
Riverside Inn Hannibal

Lighthouse Inn & Suites

Lighthouse Inn & Suites
4.0 star property
25.8 km from Mississippi River
8.8 out of 10, Excellent, (23)
"Very nice room, close enough to walk to riverfront attractions. "
United States
Robert
The price is ₹15,268
₹17,536 total
includes taxes & fees
16 Dec - 17 Dec
Lighthouse Inn & Suites

Best Western On The River

Best Western On The River
2.5 star property
25.3 km from Mississippi River
8.6 out of 10, Excellent, (1003)
"Great stay! Clean and cozy!!"
United States
Courtney
The price is ₹9,132
₹10,488 total
includes taxes & fees
18 Dec - 19 Dec
Best Western On The River

Town & Country Inn and Suites

Town & Country Inn and Suites
2.5 star property
45.2 km from Mississippi River
9.2 out of 10, Wonderful, (895)
"Staff extremely helpful and kind"
United States
Sandra
Town & Country Inn and Suites

Stoney Creek Inn Quincy

Stoney Creek Inn Quincy
2.0 star property
46.5 km from Mississippi River
8.8 out of 10, Excellent, (1008)
"Always love staying here"
United States
Ashlynn
Stoney Creek Inn Quincy

Holiday Inn Quincy East by IHG

Holiday Inn Quincy East by IHG
3.0 star property
46.1 km from Mississippi River
8.8 out of 10, Excellent, (603)
"Overall very nice property. "
United States
Jeffrey
The price is ₹10,037
₹11,440 total
includes taxes & fees
2 Jan - 3 Jan 2026
Holiday Inn Quincy East by IHG

Heritage Hotel Quincy

Heritage Hotel Quincy
2.0 star property
47.8 km from Mississippi River
8.8 out of 10, Excellent, (273)
"Room was very clean Breakfast was satisfying "
United States
Mark
The price is ₹7,690
₹8,765 total
includes taxes & fees
30 Dec - 31 Dec
Heritage Hotel Quincy

Quality Inn & Suites Quincy - Downtown

Quality Inn & Suites Quincy - Downtown
2.5 star property
47.8 km from Mississippi River
8.8 out of 10, Excellent, (447)
"It was in a very quite area and easy to find places to est. able to explore the Mississippi river. "
United States
James
The price is ₹10,172
₹11,594 total
includes taxes & fees
1 Jan - 2 Jan 2026
Quality Inn & Suites Quincy - Downtown

Quality Inn & Suites Hannibal West

Quality Inn & Suites Hannibal West
2.5 star property
30 km from Mississippi River
8.0 out of 10, Very good, (1012)
"Very friendly staff. "
United States
Lawrence
The price is ₹7,113
₹8,240 total
includes taxes & fees
4 Jan - 5 Jan 2026
Quality Inn & Suites Hannibal West

Fairfield Inn & Suites Quincy

Fairfield Inn & Suites Quincy
2.5 star property
46 km from Mississippi River
8.6 out of 10, Excellent, (335)
"We were very pleased with our stay. The room was clean and the staff was VERY friendly. We were also VERY impressed the breakfast. We would definitely stay there again."
United States
Julie
The price is ₹9,915
₹11,301 total
includes taxes & fees
28 Dec - 29 Dec
Fairfield Inn & Suites Quincy

Comfort Inn & Suites - Hannibal

Comfort Inn & Suites - Hannibal
2.5 star property
26.2 km from Mississippi River
7.6 out of 10, Good, (659)
"Below average facility. Needs some upgrades and could use a good cleaning. Staff was helpful."
United States
JACQUI
The price is ₹7,302
₹8,657 total
includes taxes & fees
28 Dec - 29 Dec
Comfort Inn & Suites - Hannibal

Oak Hill Inn & Suites

Oak Hill Inn & Suites
2.5 star property
71.8 km from Mississippi River
9.2 out of 10, Wonderful, (866)
"Great service & room .... highly recommend "
United States
Chad
The price is ₹9,521
₹10,851 total
includes taxes & fees
16 Dec - 17 Dec
Oak Hill Inn & Suites

WoodSpring Suites St Peters-OFallon

WoodSpring Suites St Peters-OFallon
2.5 star property
93.4 km from Mississippi River
9.8 out of 10, Exceptional, (18)
"The room was super clean and tidy. The staff was very friendly and overall a great experience. "
United States
Fred
The price is ₹6,691
₹7,692 total
includes taxes & fees
17 Dec - 18 Dec
WoodSpring Suites St Peters-OFallon

Motel 6 Hannibal, MO

Motel 6 Hannibal, MO
2.0 star property
26.1 km from Mississippi River
7.4 out of 10, Good, (1003)
"Very clean rooms and staff is very friendly "
United States
Sherrie
The price is ₹5,244
₹6,022 total
includes taxes & fees
1 Jan - 2 Jan 2026
Motel 6 Hannibal, MO

Days Inn by Wyndham Hannibal

Days Inn by Wyndham Hannibal
2.0 star property
26.4 km from Mississippi River
7.4 out of 10, Good, (215)
"Left before breakfast great cup of coffee"
United States
David
The price is ₹5,697
₹6,542 total
includes taxes & fees
29 Dec - 30 Dec
Days Inn by Wyndham Hannibal

Holiday Inn Express & Suites Wentzville St Louis West by IHG

Holiday Inn Express & Suites Wentzville St Louis West by IHG
2.5 star property
86.2 km from Mississippi River
9.4 out of 10, Exceptional, (838)
"Excellent location, very clean and comfortable, great hot breakfast, and amazing staff!"
United States
Shannon
The price is ₹9,946
₹11,935 total
includes taxes & fees
2 Jan - 3 Jan 2026
Holiday Inn Express & Suites Wentzville St Louis West by IHG

Super 8 by Wyndham Hannibal

Super 8 by Wyndham Hannibal
2.0 star property
26.3 km from Mississippi River
7.2 out of 10, Good, (1000)
"My stay was excellent staff very friendly and breakfast was always great "
United States
Sherrie
The price is ₹5,290
₹6,075 total
includes taxes & fees
1 Jan - 2 Jan 2026
Super 8 by Wyndham Hannibal
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top Mississippi River Hotel Reviews

Hotels near other Mississippi River attractions

Find out more about Mississippi River

Top reasons to visit Mississippi River

  • Vibrant Live Music Scene: Experience the lively musical performances that echo the rich cultural heritage of the Mississippi River region.
  • Scenic Hiking Trails: Immerse yourself in nature with friendly hiking trails that showcase the picturesque surroundings.
  • Historic Attractions: Discover fascinating caves, historic houses, and charming lighthouses that highlight the area's heritage.
  • Family-Friendly Activities: Enjoy a variety of excursions suitable for families, including local baseball games and art galleries.
  • Diverse Accommodation Options: Choose from cosy bed and breakfasts to inviting guesthouses catering to all types of travellers.

Find great hotels near Mississippi River

Discover a charming selection of accommodations along the iconic Mississippi River, perfect for every type of traveller. From cosy bed and breakfasts to inviting guesthouses, you'll find options that cater to families and those seeking a romantic getaway or a touch of history. Enjoy affordable rates at various motels and convenient highway hotels, ensuring a delightful stay while exploring the scenic beauty of this legendary waterway.

  • Best Western On The River: Situated 25.7km from the Mississippi River, Best Western On The River offers a family-friendly and business-oriented experience in the heart of the city. This hotel combines comfort with convenience, featuring a well-equipped business centre and meeting rooms for corporate travellers. Families will appreciate amenities such as cribs (available for a fee) and a secure pool area with a gate. Its central location makes it an ideal base for exploring the local attractions while ensuring that both business and leisure needs are met.
  • Super 8 by Wyndham Bowling Green: Located 24.1km from the Mississippi River, Super 8 by Wyndham Bowling Green provides a welcoming atmosphere with a focus on convenience. Guests can start their day with a complimentary breakfast that includes daily options and a restaurant offering breakfast to-go. The hotel is equipped with entertainment features such as a DVD player and premium television channels, ensuring that guests can unwind after a day of exploration. With its budget-friendly pricing and essential amenities, this hotel is perfect for travellers looking for a hassle-free stay.
  • River's Edge Motel: Just 12.9km from the Mississippi River, River's Edge Motel caters to pet lovers seeking a comfortable getaway. This charming motel welcomes a range of pets, ensuring that your furry friends can accompany you on your holiday. With policies in place for service animals and specific pet restrictions, guests can enjoy peace of mind while staying. The relaxed atmosphere and proximity to the river make it an excellent choice for those looking to enjoy nature with their pets in tow.

Where to stay near Mississippi River

Exploring the enchanting regions along the Mississippi River offers a delightful blend of friendly atmospheres and family-friendly excursions. Visitors can indulge in antebellum hospitality, admire local art galleries, and enjoy relaxing strolls through charming neighbourhoods. With easy access to courses and activities, the Mississippi River promises a memorable experience steeped in American culture and scenic beauty. Discover the vibrant spirit of the area and create lasting memories on your vacation.

  • Ashburn: Nestled a mere 1.3km from the Mississippi River, Ashburn is a charming village that invites sports enthusiasts and nature lovers alike. While the number of visitors remains consistent throughout the year, the peak season occurs from June to August, perfect for enjoying the local sports facility and stadium. Ashburn offers a delightful escape with its friendly atmosphere and opportunities for engaging in various athletic activities. Whether you're a participant or a spectator, you'll find plenty to appreciate in this quaint locale.
  • Louisiana: Located approximately 14.5km from the Mississippi River, Louisiana is a vibrant city known for its stunning outdoor scenery and romantic settings. The best time to visit is during the peak months of April, July, and September, when the weather is perfect for exploring the recreational areas and trails. Louisiana boasts an array of activities, including an amusement park that provides fun for the entire family. With its picturesque rivers, tranquil lakes, and expansive national state park, this city is a haven for those seeking adventure and relaxation amidst nature.
  • New Canton: Just 11.3km from the mighty Mississippi River, New Canton offers a seasonal travel experience that peaks during the months of January to February, April, August, and November. Visitors are drawn to this charming city for its breathtaking scenery and outdoor adventures. The local recreational areas are perfect for hiking and exploration, while the nearby national state park showcases the region's natural beauty. New Canton is ideal for those who crave adventure and wish to immerse themselves in the tranquil surroundings of the great outdoors.

Things to do near Mississippi River

Exploring the Mississippi River offers a wealth of activities, including engaging in local baseball games, enjoying various sports, and soaking up live music performances. For those who appreciate nature, the region boasts friendly hiking trails that allow visitors to immerse themselves in the picturesque surroundings. Whether you're seeking vibrant entertainment or tranquil outdoor experiences, the Mississippi River has something for everyone.

Shopping

The nearest shopping experience is at Quincy Mall, located 46.7km away from the Mississippi River. This shopping centre offers a vibrant mix of entertainment and family-friendly activities. If you're up for a drive, explore the charming boutiques and local shops along the riverbanks for unique souvenirs.

Recreation

Enjoy a round of golf at Old Orchard Country Club, located 33.8km from the Mississippi River, surrounded by lush landscapes. Norwoods Golf Club offers a similar experience 32.2km away, while Westview Golf Course, 43.5km from the river, provides excellent outdoor vibes for sports enthusiasts.

Adventure

At Greeman Tennis Center, located 48.3km from the Mississippi River, you can indulge in thrilling tennis matches amidst vibrant adventure vibes. This venue offers a dynamic atmosphere perfect for sports enthusiasts looking to enjoy a blend of competition and recreation while soaking in the scenic surroundings.

Nightlife

Experience the charm of the Planters Barn Theater, just 25.7km from the Mississippi River, offering a delightful mix of culture and romance. Alternatively, enjoy the Bluff City Theater, also 25.7km away, perfect for family-friendly entertainment and a lively atmosphere.

*Distances are measured in a straight line; actual driving distances may vary depending on the route.

Booking tips and Expedia advantages for Mississippi River

For a budget-friendly trip to the Mississippi River, consider visiting between December and February when prices are lower. Sundays are the cheapest days to stay, while Saturdays tend to be pricier. Use Expedia’s search tool to find affordable accommodations by filtering for eco-certified hotels or arranging your stay from lowest to highest price. Look for package deals that combine hotels, flights, and activities to save even more. Don’t forget to check for additional fees and availability to secure the best hotel deals possible.

  • The most and least expensive months on average to stay in a hotel: The cheapest months to stay around Mississippi River are December to February, where the prices are slightly lower. This is in comparison to May to July, where prices are slightly higher.
  • The most and least expensive days on average to stay in a hotel: The least expensive day to stay around Mississippi River is Sunday. The most expensive day to stay around Mississippi River is Saturday.
  • Find cheap hotels on Expedia: Utilise Expedia's search tool to narrow down your options based on your budget, preferred location, and the type of accommodation you desire. For instance, selecting the Eco-certified filter will showcase sustainable and environmentally-friendly hotels currently available. To find the best prices and offers, simply arrange the price filter from lowest to highest.
  • Consider bundling your trip: You may find that you can save some money by combining your hotel reservations along the Mississippi River with your flights and activities through an Expedia package.

Find the best attractions near Mississippi River

Whether you're seeking cultural experiences, outdoor adventures, or simply a touch of history, the Mississippi River offers a wealth of attractions. Explore fascinating caves, historic houses, and charming lighthouses that showcase the region's rich heritage. This diverse range of points of interest ensures that every traveller can find something memorable to enjoy during their visit to this iconic American landmark.

  • Mark Twain Cave: Experience the thrill of adventure as you explore this fascinating cave, located 19.3km from the Mississippi River. The cave showcases stunning geological formations and provides an exhilarating outdoor experience.
  • Mark Twain Boyhood Home and Museum: Situated 25.7km away from the river, this historic house offers a glimpse into the early life of the famed author, Mark Twain. Immerse yourself in the rich culture and history that shaped his literary genius.
  • Sawyer's Creek Fun Park: Just 22.5km from the Mississippi River, this urban park is perfect for families. Enjoy a variety of outdoor activities amidst a vibrant city atmosphere, making it an ideal spot for relaxation and fun.

The nearest major airports for your trip to Mississippi River

When planning your visit to the Mississippi River, you can fly into Quincy, IL (UIN-Quincy Regional-Baldwin Field), located 43.5km away. Nearby hotel options include the 3-star Holiday Inn Quincy East and the Town & Country Inn and Suites, both around 7-12.9km from the airport, providing convenient access. Alternatively, you can also fly into St. Louis, MO (SUS-Spirit of St. Louis), which is 107.8km away. Recommended hotels near St. Louis Airport include the 4.5-star Ameristar Casino Resort and Spa and The Ritz-Carlton Sarasota, both offering comfortable accommodations within a short drive from the airport.

Frequently asked questions

What's the area like around Mississippi River?
Mississippi River is located in an area that travellers like for its baseball games. When you want to settle in and find a place to stay, take a look at some of the hotels and other accommodation options that Expedia offers in the area.
What's the best hotel to stay close to Mississippi River?
Pear Tree Inn St. Louis Airport is one of the top choices for your stay based on our traveller data, and this hotel offers free breakfast and free parking. You'll find it 69.9 mi (112.5 km) from Mississippi River. Other good options around the area include Magnolia Hotel St. Louis, a Tribute Portfolio Hotel and Hyatt Regency St. Louis at The Arch.
If I need to cancel the hotel reservation for my stay near Mississippi River, will I receive a refund?
Yes! Most room reservations are fully refundable as long as you cancel before the hotel's cancellation deadline, which in most cases is within 24 or 48 hours of your scheduled arrival. If you have a reservation that's non-refundable, it may still be possible to cancel it and get a refund within a 24-hour period of booking. Add dates, click "Search", then use the "fully refundable" filter to review the best deals near Mississippi River.

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