Calle 50

A cityscape with modern skyscrapers and lush green trees.
A cityscape with modern skyscrapers, including a distinctive twisting tower.
A modern, spiraling skyscraper with a unique design, surrounded by other buildings in an urban setting.
A harbor with several boats docked in the foreground and a city skyline in the background.
A city skyline with tall buildings and palm trees.

Stay near popular Calle 50 attractions

Calle 50

You can find out about the history of Panama City when you stop by Calle 50. Discover the area's shops or seek out its local tours.
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Top Hotel Deals

Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

5 out of 5
Calle 50, Urb. Marbella Panama City Panama
Hotel Riu Plaza Panama
Courtyard by Marriott Panama Multiplaza Mall

Courtyard by Marriott Panama Multiplaza Mall

4 out of 5
Via Israel Multiplaza Pacific Mall Panama City Panama
Courtyard by Marriott Panama Multiplaza Mall
Megapolis Hotel Panamá

Megapolis Hotel Panamá

4.5 out of 5
Avenida Balboa Panama City
Megapolis Hotel Panamá
Principe Hotel and Suites

Principe Hotel and Suites

3 out of 5
Via Argentina Panama City Panama
Principe Hotel and Suites
W Panama

W Panama

5 out of 5
Calle Aquilino de la Guardia & Calle 50 Panama City
W Panama
Waldorf Astoria Panama

Waldorf Astoria Panama

5 out of 5
47th St. & Uruguay Street Panama City Panama
Waldorf Astoria Panama
Las Americas Golden Tower Panama

Las Americas Golden Tower Panama

4 out of 5
Av. Balboa con Calle 53 Panama City Panama
Las Americas Golden Tower Panama
Hospedium Princess Hotel Panama

Hospedium Princess Hotel Panama

3.5 out of 5
Calle 53 Marbella y Avenida 5a B sur Panama City Panama
Hospedium Princess Hotel Panama
The Executive Hotel

The Executive Hotel

3.5 out of 5
Calle 52 Panama City Panama
The Executive Hotel
See all 1,668 properties in Calle 50
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.