Compare and book 5 Star hotels in Florida Keys, United States of America
Change your mind
Be picky
Check availability on Florida Keys 5 Star Hotels
Top Florida Keys 5 Star Hotels
Cheeca Lodge & Spa
Cheeca Lodge & Spa
Isla Bella Beach Resort & Spa
Isla Bella Beach Resort & Spa
Explore similar 4-star hotels
Hawks Cay Resort
Learn more about Florida Keys
Discover the seaside area of Florida Keys—live music, beaches and top sights like Duval Street.
Top Florida Keys Hotel Reviews
Cheeca Lodge & Spa
Isla Bella Beach Resort & Spa
Find out more about Florida Keys
Find out more about Florida Keys
Stay in Luxury: 5 Star Hotels in Florida Keys
There's nothing wrong with enjoying the finer things in life. Indulge your every desire on your upcoming leisure time. Treat yourself with a stay in a 5-star hotel during your Florida Keys trip. You'll join the multitudes of holidaymakers who have made Florida Keys so fashionable recently. You can also expect excellent customer service from these hotels, so get ready to kick back and indulge. Don't wait any longer. Reserve one of our 5-star hotels in Florida Keys and indulge in the finer things in life for a while.
5-Star Hotels in Florida Keys
You'll have a wonderful time at one of these 5-star hotels. Exceptional customer care, luxurious bedding, and deeply relaxing spa offerings are waiting for you. You're sure to find exactly the accommodation you need. You can also expect excellent customer service from these hotels, so get ready for a wonderful adventure. What kind of amenities will make your stay a wonderful one? 24-hour room service, so you can order that berry tart in the wee hours of the morning? A body scrub that will leave you feeling refreshed and alive? Butler services? Whatever it is your heart desires, you're bound to find it here. Don't want to take our word for it? Explore our listings and pick the perfect accommodation for your needs.
But you aren't going to spend your entire holiday in your room, of course. You're in luck. From doing a bit of shopping to embracing the great outdoors, you'll never be bored on this retreat. No matter what's on your agenda, the 5-star hotels in Florida Keys are waiting for you to relax after an exciting day.
Make Your Escape
The results are in, and Florida Keys 5-star hotels are the place to be when you book your next holiday. If you've been dreaming about a holiday set here, then go ahead and book it. It's time to plan your next great escape -- this is a great time to find 5-star hotel deals in Florida Keys! Choose one of our Florida Keys 5-star hotels today and soothe yourself in luxe surroundings at your convenience.
Expedia India is rated 4 stars by Feefo based on 1038 reviews
Explore a world of travel with Expedia
Explore a world of travel with Expedia
Hotels in Florida Keys by Star Rating
Accommodation near Florida Keys attractions
- Hotels near Duval Street
- Hotels near Southernmost Point
- Hotels near Mallory Square
- Hotels near Smathers Beach
- Hotels near John Pennekamp Coral Reef State Park
- Hotels near Florida Keys Beaches
- Hotels near South Beach
- Hotels near Biscayne National Park
- Hotels near Fiesta Key
- Hotels near Florida Keys Visitor Center - Key Largo
Choose Your Florida Keys Hotel Style
- Beach Resorts & Hotels in Florida Keys
- Business Hotels in Florida Keys
- Cheap Hotels in Florida Keys
- Family-Friendly Hotels in Florida Keys
- Golf Hotels in Florida Keys
- Historic Hotels in Florida Keys
- Hotels near Museums in Florida Keys
- Hotels with Air Conditioning in Florida Keys
- Hotels with Balcony in Florida Keys
- Hotels with Breakfast in Florida Keys
- Hotels with Connecting Rooms in Florida Keys
- Hotels with Entertainment in Florida Keys
- Hotels with Gym in Florida Keys
- Hotels with Hot Tubs in Florida Keys
- Hotels with Laundry Service in Florida Keys
- Hotels with Parking in Florida Keys
- Hotels with Parking in Florida Keys
- Hotels with Restaurant in Florida Keys
- Hotels with Room Service in Florida Keys
- Hotels with Swimming Pool in Florida Keys
- Hotels with Views in Florida Keys
- Hotels with Wifi in Florida Keys
- Hotels with a Bar in Florida Keys
- Hotels with smoking rooms in Florida Keys
- Luxury Hotels in Florida Keys
- Marina Hotels in Florida Keys
- Pet-Friendly Hotels in Florida Keys
- Romantic Hotels in Florida Keys
- Shopping Hotels in Florida Keys
- Spa Hotels in Florida Keys
- Sports Hotels in Florida Keys
- Wedding Hotels in Florida Keys
More accommodation types in Florida Keys
- Holiday Homes in Florida Keys
- Cottages in Florida Keys
- Resorts in Florida Keys
- Apartments in Florida Keys
- Motels in Florida Keys
- Villas in Florida Keys
- Condo Rentals in Florida Keys
- Aparthotels in Florida Keys
- Houseboats in Florida Keys
- Guest Houses in Florida Keys
- B&B in Florida Keys
- Cabin Rentals in Florida Keys
- Lodges in Florida Keys
Explore more hotels
- Waterside Suites & Marina
- Bayside Inn Key Largo
- Lime Tree Bay Resort
- Playa Largo Resort & Spa, Autograph Collection
- Three Waters Resort and Marina, Islamorada, a Tribute Portfolio Resort
- Rock Reef Resort
- Courtyard by Marriott Faro Blanco Resort
- Faro Blanco Resort & Yacht Club Marathon, Curio by Hilton
- Reefhouse Resort & Marina
- La Siesta Resort & Villas
- The Pelican Key Largo Cottages
- Tranquility Bay Beachfront Hotel and Resort
- Creekside Inn Islamorada
- Drift Hotel
- Coconut Cay Resort & Marina
- Rainbow Bend Resort
- Hadley Resort and Marina
- Hampton Inn Marathon - Florida Keys
- Marina Del Mar Resort and Marina
- Fisher Inn Resort & Marina
More ways to book
Expedia's Latest Trends
- Hotels in Atlanta
- Hotels in New Haven
- Hotels in Seattle
- Cheap Hotels in Chicago
- Hotels in Philadelphia
- Hotels in Santa Clara
- Hotels in Berkeley Heights
- Hotels in San Francisco
- Hotels in New York
- Cheap Hotels in New York
- Hotels with Early Check-in in New York
- Hotels in Erie
- Hotels in Ames
- Hotels in West Lafayette
- Hotels in Newark
- Hotels near Mars Desert Research Center
- Hotels in Las Vegas
- Hotels in Los Angeles
- Hotels in Salt Lake City
- 5 Star Hotels in Silicon Valley
- Hotels in Miami
- Hotels in Chicago
- Hotels in San Jose
- Hotels in Ann Arbor