All Hotels by Independent in O'Fallon - 2026 Updated Prices

This is the skyline at sunrise. It is situated along the Mississippi River. There are riverboats on the water with the St. Louis Arch in clear view.

Change your mind
Book hotels with free cancellation
Treat yourself
Sign in to save 10% or more on thousands of hotels
Sign in
Be picky
Search almost a million properties worldwide

Check prices for these dates

Tonight

Tomorrow

This weekend

Next weekend

Save an average of 15% on thousands of hotels when you're signed in

Top O'Fallon Hotel Reviews

Hyatt Regency St. Louis at The Arch

8/10 Good

"Good location. Nice lobby with a variety of food options."

21C Museum Hotel St Louis

6/10 Okay

"The hotel is very interesting in the best way, very cozy. The restaurant and coffee shops are also great. The coffee shop was not very clean, even in the morning we got there as soon as they opened and it is not cleaned. The floor had lots of crumbs and stuff all over it and the chairs were pretty nasty. Our room was nice and big however same as the coffee shop lacked in the cleaning department. Our shower faucet was broken and instead of body wash the shower had hand wash instead which was odd. The bathroom also don't have a fan so showers get very steamy. The room carpet was not vacuumed. The beds thankfully were clean. Overall the hotel is nice just needs to up their cleaning protocols for sure. The staff was very friendly."

Magnolia Hotel St. Louis, a Tribute Portfolio Hotel

4/10 Poor

"Our stay was the day of a Cardinals/Cubs game, and the hotel could not handle the amount of people staying there. We waited an hour and a half to check in, almost getting to the game late, and the next morning it was over an hour to get our car from the valet."