This hotel was a very good choice. It's got a really good location right next to Berlin's main station which was very convenient for me as I had an early train journey in the morning and I could walk to the station from my hotel. It was also quick an easy to get from Berlin Tegel airport - one half an hour bus journey that dropped me outside the main station from where I could walk. It was also very close tot he Naturkunde Museum undeground station from which there were plenty of connections to the S Bahn from Fridrichstrase station.
The location itself was pretty quiet but there were some nice cafes and restaurants around - Balzac Cafe which is a good coffee chain and a really nice vietnamese restaurant. Also some shops.
At night after the traffic stops, it's easy to walk from the centre of Berlin - straight walk from the Brandenburg Gate albeit a little long.
The check in/check out staff were very helpful. Also the room was fairly large and comfortable with nice bathroom, comfortable bed and decent furniture. The view wasn't great but I didn't spend much time in the room for it to bother me. The only thing was that the room got really hot. When I left the window open, I think it was set to automatically close which freaked me out when i first noticed. Luckily there was a fan which made the room more bearable.
All in all, this was a great choice as it was good standard and the location was excellent especially if you travel through the main station or Tegel airport.